CAS Number: 85622-93-1

Formula: C6H6N6O2

Molecular Weight: 194.151 

Method of Analysis: USP 41

Application: 

Glioblastoma Multiforme (GBM), Advanced Melanoma

Mechanism:

Temozolomide is not directly active but undergoes rapid nonenzymatic conversion at physiologic pH to the reactive compound 5-(3-methyltriazen-1- yl)-imidazole-4-carboxamide (MTIC). The cytotoxicity of MTIC is thought to be primarily due to alkylation of DNA. Alkylation (methylation) occurs mainly at the O6 and N7 positions of guanine

Storage conditions: preserve in well-closed containers, and store at room temperature.

Packaging:  The final product is packed in polyethylene nylon plastic bag and then packaged in a 3-layered aluminum foil.