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On the mechanism of genotoxicity of ethephon on embryonic fibroblast cells

Ethephon is one of the most widely used plant growth regulator in agriculture that its application has been increased in recent years. Many reports have raised concern over the safety of this organophosphorus compound. The aim of the current study was to assess the potential genotoxic effect of ethe..

۱۴۰۰/۰۸/۰۱ 1258 بیشتر بخوانید

Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid

Oxidative stress has been involved in the aging process and the pathogenesis of type-2 diabetes, which is a serious health problem worldwide. This study investigates the anti-aging, anti-apoptotic, and antioxidant properties of alpha-lipoic acid (ALA), aiming to improve aged rat pancreatic cells. In..

۱۴۰۰/۰۸/۰۱ 1275 بیشتر بخوانید

α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress

Senescence is a process characterized by an irreversible growth arrest in cells and induced by oxidative stress. In the current study, anti-aging potential of a well-known antioxidant, α-lipoic acid (α-LA), in rat embryonic fibroblast (REF) cells was assessed. In this regard, oxidative stress, infla..

۱۴۰۰/۰۸/۰۱ 1229 بیشتر بخوانید

Alteration of gene expression profile in mouse embryonic stem cells and neural differentiation deficits by ethephon

Ethephon, a member of the organophosphorus compounds, is one of the most widely used plant growth regulators for artificial ripening. Although million pounds of this chemical is being used annually, the knowledge regarding its molecular toxicity is yet not sufficient. The purpose of this study was t..

۱۴۰۰/۰۸/۰۱ 1242 بیشتر بخوانید

The mechanisms of cellular crosstalk between mesenchymal stem cells and natural killer cells: Therapeutic implications

Mesenchymal stem cells (MSCs) are mesenchymal precursors of various origins, with well-known immunomodulatory effects. Natural killer (NK) cells, the major cells of the innate immune system, are critical for the antitumor and antiviral defenses; however, in certain cases, they may be the main culpri..

۱۴۰۰/۰۸/۰۱ 1252 بیشتر بخوانید

Amino acid

We describe the design and synthesis of some 9 hypothetical heptapeptides specifically to overcome the 10 neoplastic activity of ras oncogene and their anti-cancer 11 activities were studied. To improve the anti-cancer activity 12 of the synthesized peptides, their structure modifications 13 we..

۱۳۹۹/۰۹/۲۲ 1413 بیشتر بخوانید

Synthetic and biological identities of polymeric nanoparticles influencing the cellular delivery: An immunological link

Bio-nano interface investigation models are mainly based on the type of proteins present on corona, bio-nano interaction responses and the evaluation of final outcomes. Due to the extensive diversity in correlative models for investigation of nanoparticles biological responses, a comprehensive mod..

۱۳۹۹/۰۷/۱۴ 1571 بیشتر بخوانید

Protein corona variation in nanoparticles revisited: A dynamic grouping strategy

Bio-nano interface investigation models are mainly based on the type of proteins present on corona, bio-nano interaction responses and the evaluation of final outcomes. Due to the extensive diversity in correlative models for investigation of nanoparticles biological responses, a comprehensive mod..

۱۳۹۹/۰۷/۱۴ 0 بیشتر بخوانید

The effect of pore structure

The effect of pore structure of collagen scaffold on cultured human chondrocytes in cartilage tissue engineering

۱۳۹۹/۰۷/۱۴ 1693 بیشتر بخوانید