Triptorelin is a synthetic decapeptide agonist analogue of naturally occurring luteinizing hormone-releasing hormone (LHRH). LHRH is also known as gonadotropin releasing hormone (GnRH). Triptorelin acts as a potent inhibitor of gonadotropin secretion when given continuously and in therapeutic doses. Following the first administration, there is a transient surge in circulating levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol. Chronic and continuous administration, usually 2 to 4 weeks after initiation of therapy, desensitizes pituitary LHRH receptors and inhibits LH and FSH secretion and consequently marked reduction of testicular and ovarian steroidogenesis is observed. In men, a reduction of serum testosterone concentration to a level typically seen in surgically castrated men is obtained. As a result, tissues and functions that depend on these hormones for maintenance become quiescent. These effects are usually reversible after cessation of therapy.
Storage conditions: Store between 2- 8o C protected from light
Packaging: glass vials