Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner. The suppression of LH, which is more pronounced than FSH, is maintained by continuous treatment. An initial release of endogenous gonadotropins has not been detected with Cetrorelix, which is consistent with an antagonist effect.
Some studies suggest that LHRH antagonists, such as cetrorelix, inhibit the gene expression of pituitary LHRH receptor indirectly by counteracting the stimulatory effect of LHRH.
Packaging: glass vial
Storage conditions: Store between 2- 8°C , protected from light